Dermatoglyphic Profiles of Competitive Athletes: CrossFit and Ultra-Marathon / Perfiles Dermatoglíficos de Deportistas Competitivos: CrossFit y Ultramaratón

SUMMARY: In the sports field, sports are usually classified according to the predominance of the energy system used during the competition; sports like Crossfit and ultra-marathon could be totally opposite due to the needs of athletes to achieve good places. Due to the above, the objective was established to compare the dermatoglyphic profiles of CrossFit and Ultra-marathon athletes according to the predisposition of the energy systems, aerobic and anaerobic, used in the competitions. Cross-sectional descriptive study, where the dermatoglyphic profile of 21 athletes of national presence (10 crossfit and 11 ultra-marathon runners) was determined, through the Computerized Dermatoglyphic System, brand Salus Dermatoglifia, according to the Cummins and Midlo protocol, which consists of taking the fingerprints of the 10 fingers of the hands. The fingerprint designs of the human being (arch, loop and whorl) and the elements contained in them (nucleus and delta) were analyzed, differences were established through the Analysis of Variance test in the SPSS V.25 statistical package. The results show significant differences between the average scores of the line count of both disciplines (108 and 165), being higher in ultra-marathon runners, associated with greater aerobic resistance. Another significant and relevant finding was the presence of arch-type fingerprints only in CrossFit athletes associated, along with low line count, with strength and power. It is concluded that Crossfit and Ultra-marathon athletes have dissimilar natural physical characteristics, which is why they participate and excel in different sports where they have enhanced their natural physical abilities through training.

En el ámbito deportivo, los deportes suelen clasificarse según el predominio del sistema energético utilizado durante la competición; Deportes como el Crossfit y la ultramaratón podrían ser totalmente opuestos debido a las necesidades de los deportistas de conseguir buenos lugares. Debido a lo anterior, se estableció como objetivo comparar los perfiles dermatoglíficos de atletas de CrossFit y Ultramaratón según la predisposición de los sistemas energéticos, aeróbico y anaeróbico, utilizados en las competencias. Estudio descriptivo transversal, donde se determinó el perfil dermatoglífico de 21 deportistas de presencia nacional (10 crossfit y 11 ultramaratonistas), a través del Sistema Dermatoglífico Computarizado, marca Salus Dermatoglifia, según el protocolo Cummins y Midlo, el cual consta de tomando las huellas dactilares de los 10 dedos de las manos. Se analizaron los diseños dactilares del ser humano (arco, asa y verticilo) y los elementos contenidos en ellos (núcleo y delta), se establecieron diferencias mediante la prueba de Análisis de Varianza en el paquete estadístico SPSS V.25. Los resultados muestran diferencias significativas entre las puntuaciones medias del recuento de líneas de ambas disciplinas (108 y 165), siendo superiores en los corredores de ultramaratón, asociado a una mayor resistencia aeróbica. Otro hallazgo significativo y relevante fue la presencia de huellas dactilares tipo arco sólo en atletas de CrossFit asociadas, junto con un bajo número de líneas, con fuerza y potencia. Se concluye que los atletas de Crossfit y Ultramaratón tienen características físicas naturales disímiles, por lo que participan y destacan en diferentes deportes donde han potenciado sus capacidades físicas naturales a través del entrenamiento.

Estudio Piloto Comparativo entre la Identificación Dactiloscópica y Poroscópica con Fines de Identificación Humana en el Perú / Comparative Pilot Study Between Dactyloscopy Identification and Poroscopy for Human Identification Purposes in Peru

La dactiloscopía o papiloscopía corresponde al estudio científico de las impresiones digitales, palmares y plantares, que tiene por finalidad la identificación infalible o indubitada del individuo. Existen tres niveles para identificar con mayor certeza nivel 1 (tipo o patrón dactilar), el nivel 2 (minucias o puntos característicos) y el nivel 3 (poroscopia y crestoscopia). Por ello, es necesario analizar las características de las impresiones dactilares directas y las huellas dactilares directas con la finalidad de verificar la presencia de puntos y poros característicos para mejorar el proceso de identificación humana. Se analizaron 80 muestras (54 mujeres y 26 hom- bres). A partir de ellos, se capturaron 800 impresiones y 800 huellas dactilares directas con tampón dactilar y polvo black. En huellas con tampón se identificaron 71.25 % y 1.25 % con 14 y 6 Puntos Característicos respectivamente y en grupos de poros el 84 % y 35 % para un grupo de 1 y grupos de 7 y 8 poros respectivamente. Con polvo black solo se identificaron Puntos Característico y no Poros. La cantidad de poros en hombres fue mayor igual a 10 (LR= 2.08) y en mujeres menor igual a 6 (LR= 1.93). Los grupos de poros fueron para hombres menores o iguales a 12 poros (LR= 1.04) y mayores o iguales a grupos de 13 poros (LR=1.28) para mujeres. Se consiguieron identificar grupos de poros con tampón dactilar pero no con polvos químicos lo que podría emplearse para implementar un protocolo para el uso del nivel 3 de identificación.

SUMMARY: Dactyloscopy or papiloscopy corresponds to the scientific study of digital, palmar and plantar impressions, whose purpose is the infallible or indubitable identification of a subject. There are three levels to identify with greater certainty level 1 (type or fingerprint pattern), level 2 (minutiae or characteristic points) and level 3 (poroscopy and crestoscopy). Therefore, it is necessary to analyze the characteristics of direct fingerprints and direct fingerprints in order to verify the presence of characteristic points and pores to improve the human identification process. 80 samples (54 women and 26 men) were analyzed. Of these, 800 impressions and 800 direct fingerprints with fingerprint buffer and black powder were captured. In footprints with buffer, 71.25 % and 1.25 % were identified with 14 and 6 Characteristic Points respectively and in groups of pores 84 % and 35 % for a group of 1 and groups of 7 and 8 pores respectively. With black powder, only Characteristic Points and no Pores were identified. The number of pores in men was greater than 10 (LR= 2.08) and in women less than 6 (LR= 1.93). The groups of pores were less than or equal to 12 pores (LR= 1.04) for men and greater than or equal to groups of 13 pores (LR=1.28) for women. It was possible to identify groups of pores with a fingerprint buffer but not with chemical powders, which could be used to implement a protocol for the use of level 3 identification.

Dermatoglifia Aplicada à Fonoaudiologia: possibilidade de interpretação / Dermatoglyphics applied to Speech Therapy: possibility of interpretation / Dermatoglifia aplicada a la Fonoaudiología: posibilidad de interpretación

Introdução: os avanços metodológicos e tecnológicos têm se apresentado em todas as áreas da Fonoaudiologia e não seria diferente nas Ciências da Fala, especificamente na Fonética Acústica. Dermatoglifia é o estudo científico das cristas dermopapilares, encontradas na impressão digital, considerada um marcador genético e identifica habilidades físicas básicas, como força, velocidade, resistência e coordenação motora. O método dermatoglífico vem sendo utilizado no diagnóstico diferencial de algumas síndromes, assim como parte integrante de processo de avaliação da qualidade vocal de profissionais da voz falada e cantada. Objetivo: descrever uma proposta de roteiro de análise dermatoglífica (DAF), que integre a avaliação da qualidade vocal, tanto de profissionais da voz falada e cantada, quanto daqueles falantes que não usam a voz profissionalmente. Descrição: o roteiro do método dermatoglífico como possibilidade de uso para Fonoaudiologia propõe a coleta das impressões digitais, a identificação dos desenhos digitais e seu predomínio, a detecção do perfil dermatoglífico, de fórmula digital, a soma da quantidade de linhas e de deltas dos dedos das mãos e a constatação das habilidades físicas potencializadas e não-potencializadas. Considerações finais: esta comunicação aponta para a integração do método dermatoglífico ao processo avaliativo da qualidade vocal de profissionais da voz falada e cantada. Representa também uma linha de investigação acerca do enfoque das habilidades musculares de indivíduos, não apenas na área de voz, mas nas demais áreas de atuação da Fonoaudiologia, por meio do Roteiro DAF ­ Dermatoglifia Aplicada à Fonoaudiologia.

Introduction: methodological and technological advances have figured in all areas of Speech Therapy and it would not be different in speech sciences, specifically in acoustic phonetics. Dermatoglyphics is the scientific study of dermatopapillary ridges, found in fingerprints, considered a genetic marker and identifying basic physical abilities, such as strength, speed, endurance and motor coordination. The dermatoglyphic method has been used in the differential diagnosis of some syndromes, and is also an integral part of the vocal quality assessment process and spoken and singing voice professionals. Objective: to describe a proposal for a dermatoglyphic analysis script (DAF), which integrates the assessment of vocal quality, both for speaking and singing voice professionals, as well as for speakers who do not use their voice professionally. Description: the script of the dermatoglyphic method as a possible tool in Speech Therapy proposes the collection of fingerprints, the identification of the digital patterns and their predominance, the detection of the dermatoglyphic profile, of the digital formula, the sum of the number of lines and deltas of the fingers of the hands and the verification of the potentiated and non-potentiated physical abilities. Final considerations: this communication points to the integration of the dermatoglyphic method into the vocal quality assessment process of vocal and singing voice professionals. It also represents a line of inquiry about the focus on the muscular abilities of individuals, not only in the area of voice, but in other areas of activity in Speech Therapy, through the DAF Script ­ Dermatoglyphics Applied to Speech Therapy.

Introducción: Los avances metodológicos y tecnológicos se han presentado en todas las áreas de la Fonoaudiología y no sería diferente en las Ciencias del Habla, específicamente en la Fonética Acústica. La dermatoglifia es el estudio científico de las crestas dermopapilares, que se encuentran en la huella dactilar, se considera un marcador genético e identifica capacidades físicas básicas como la fuerza, la velocidad, la resistencia y la coordinación motora. El método dermatoglífico ha sido utilizado en el diagnóstico diferencial de algunos síndromes, así como parte integral del proceso de evaluación de la calidad vocal de los profesionales de la voz hablada y cantada. Objetivo: describir una propuesta de roteiro de análisis dermatoglífica (DAF), que integra la evaluación de la calidad vocal, tanto para profesionales con la voz hablada y cantada, como para aquellos locutores que no utilizan su voz profesionalmente. Descripción: el roteiro del método dermatoglífico como posibilidad de uso para la Fonoaudiología propone la toma de huellas dactilares, la identificación de dibujos digitales y su predominio, la detección del perfil dermatoglífico, de la fórmula digital, la suma del número de líneas y deltas de los dedos de las manos y la verificación de capacidades físicas potenciadas y no potenciadas. Consideraciones finales: esta comunicación apunta a la integración del método dermatoglífico al proceso de evaluación de la calidad vocal de los profesionales de la voz hablada y cantada. También representa una línea de investigación sobre el enfoque de las capacidades musculares de los individuos, no sólo en el área de la voz, sino en otras áreas de actuación de la Fonoaudiología, a través del roteiro DAF ­ Dermatoglífia aplicada a la Fonoaudiología.

Composición corporal, dermatoglifia y resistencia aeróbica en futbolistas bogotanos categoría sub 20 / Body Composition, Dermatoglyphics and Aerobic Resistance in Sub-20 Category Footballers from Bogota, Colombia

Resumen El fútbol como disciplina ha sido objeto de numerosas investigaciones que han permitido la potenciación de las cualidades de las personas deportistas para alcanzar el máximo rendimiento deportivo. El uso de nuevas herramientas ha permitido mejorar los procesos de selección de talentos y el desarrollo de las capacidades físicas, como es el caso de la dermatoglifia, que brinda información del genotipo de un individuo. El presente estudio pretende relacionar la composición corporal, la dermatoglifia y el consumo máximo de oxígeno en jugadores de fútbol categoría sub 20. La investigación fue cuantitativa, diseño no experimental, de tipo transversal. La muestra estuvo conformada por 22 futbolistas (edad 18 ± 1.1) de un club deportivo de Bogotá, a ellos se les realizó una valoración de composición corporal, se les calculó el somatotipo, se analizaron las huellas de las manos y se midió el consumo máximo de oxígeno con el Test Course Navette. Los resultados muestran predominio del somatotipo mesomorfo balanceado (53%), alta presencia de presillas "L" (66.36%), baja presencia de arcos "A" (1.82%) y un consumo máximo de oxígeno de 53.76 ± 3.73 ml/kg/min. Además, se encontraron relaciones significativas entre componentes dermatoglíficos D10-SCTL y el somatotipo endomorfo (p < 0.05), y entre el VO₂ máximo con somatotipo endomorfo y ectomorfo (p < 0.05). Se concluye que los futbolistas se caracterizan por tener una predisposición hacia la coordinación, la resistencia y la agilidad.

Abstract Soccer has generated endless research that has enhanced athlete's qualities to achieve maximum sports performance. According to the above, the use of new tools has been implemented to improve talent selection processes and develop physical abilities, as is the case with dermatoglyphics that provides information on an individual's genotype. The present study aims to relate body composition, dermatoglyphics, and maximum oxygen consumption in soccer players' category sub-20. The research had a quantitative, non-experimental, cross-sectional design. The sample comprised 22 players (age 18±1.1) from Bogota Sports Club, Colombia. They were assessed for body composition, the somatotype was calculated, handprints were analyzed, and the maximum oxygen consumption was measured with the Test Course Navette. The results show a predominance of balanced mesomorph somatotype (53%), high presence of "L" ridges (66.36 %), low presence of "A" arches (1.82%), and maximum oxygen consumption of 53.76±3.73 ml/kg/min. Furthermore, significant relationships were found between D10-SCTL dermatoglyphic components and the endomorph somatotype (p <0.05), and between the maximum VO₂ with endomorph and ectomorph somatotype (p <0.05). It is concluded that soccer players are characterized by having a predisposition towards coordination, resistance, and agility.

Resumo O futebol como disciplina tem sido objeto de inúmeras investigações que permitiram melhorar as qualidades dos desportistas para alcançar o máximo desempenho desportivo. A utilização de novas ferramentas tornou possível melhorar os processos de seleção de talentos e o desenvolvimento de capacidades físicas, como a dermatoglifia, que fornece informações sobre o genótipo de um indivíduo. O presente estudo visa relacionar a composição corporal, dermatoglifos e o consumo máximo de oxigênio nos jogadores de futebol sub-20. A pesquisa foi quantitativa, não-experimental e transversal. A amostra consistiu em 22 jogadores de futebol (18 ± 1,1 anos) de um clube desportivo de Bogotá, que foram submetidos a uma avaliação da composição corporal, foi calculado o somatotipo, foram analisadas as impressões digitais das mãos e foi medido o consumo máximo de oxigénio através do teste Course Navette. Os resultados mostram uma predominância do somatotipo mesomorfo balanceado (53%), presença elevada de presilha em "L" (66,36%), baixa presença de arcos em "A" (1,82%) e um consumo máximo de oxigênio de 53,76 ± 3,73 ml/kg/min. Além disso, foram encontradas relações significativas entre os componentes dermatoglíficos D10-SCTL e o somatotipo endomorfo (p < 0,05), e entre VO₂ máximo com somatotipo endomorfo e ectomorfo (p < 0,05). Conclui-se que os jogadores de futebol são caracterizados por uma predisposição para a coordenação, resistência e agilidade.

Dermatoglifia e condição vocal de professores universitários / Dermatoglyphy and vocal condition of professors

RESUMO Objetivo Investigar a associação entre o perfil dermatoglífico e a condição vocal dos professores de uma instituição pública de ensino superior. Métodos Participaram do estudo 49 docentes. Foram utilizados os seguintes instrumentos de coleta: questionário sociodemográfico e Índice de Triagem para Distúrbios da Voz (ITDV). As impressões digitais foram coletadas por meio do scanner Watson Mini da Integrated Biometric e a análise realizada por meio do protocolo de Cummins e Midlo. Os resultados foram expostos em frequência absoluta. Foi realizado o teste Qui-Quadrado, com nível de significância de 5%, para verificação da associação dos sintomas vocais do ITDV com o perfil dermatoglífico. Resultados houve prevalência do gênero feminino entre os docentes universitários estudados. Quanto à classificação do perfil dermatoglífico, a maioria apresentou perfil anaeróbico. Observou-se associação estatisticamente significativa apenas entre perfil dermatoglífico e carga horária semanal. Conclusão a maioria dos sujeitos de perfil anaeróbico teve maior frequência de sintomas vocais. Observou-se associação estatisticamente significativa entre carga horária semanal e perfil dermatoglífico.

ABSTRACT Purpose To investigate the association between the dermatoglyphic profile and the vocal condition of teachers at a public higher education institution. Methods 49 professors participated in the study. After signing the Informed Consent Form, the following instruments were used: sociodemographic questionnaire and Voice Disorder Screening Index (ITDV). Fingerprints were collected using the Integrated Biometric Watson Mini scanner and analysis performed using the Cummins and Midlo protocol. The results were presented in absolute frequency. The Chi-Square Test was performed, with a significance level of 5%, to verify the association of ITDV vocal symptoms with a dermatoglyphic profile. This study was approved by the Research Ethics Committee of a public higher education institution under protocol number 3,372.226. Results There was a prevalence of females among the university professors studied. As for the classification of the dermatoglyphic profile , most had an anaerobic profile. There was a statistically significant association only between dermatoglyphic profile and weekly workload. Conclusion Most subjects with an anaerobic profile had more frequency of vocal symptoms. There was a statistically significant association between weekly working hours and dermatoglyphic profile.

Dermatoglifia como medio de hallazgo de diabetes mellitus: revisión sistemática / Dermatoglyphics as a means of finding diabetes mellitus: a systematic review

Introducción. La diabetes mellitus (DM) es una de las enfermedades crónicas más comunes, siendo una de las causas principales de mortalidad de la población mun-dial. La dermatoglifia es empleada como instrumento para el hallazgo de ciertos aspectos biológicos en diferentes poblaciones. Objetivo. Reconocer, a partir de una revisión sistemática, la relevancia que tiene la dermatoglifia como medio de hallazgo de diabetes mellitus. Metodología. Revisión de literatura científica en bases de datos como Sciencedi-rect, PubMed, Scopus y BVS, en las cuales se extrajo información después de co-rrer la ecuación de búsqueda con términos MESH. Posteriormente, fueron revisados para incluir aquellos artículos relacionados con DM y dermatoglifia. Para todo el proceso se siguió la metodología PRISMA, evaluando los artículos con la escala de sesgo de Cochrane y el nivel de evidencia y recomendación con escala SIGN. Resultados. Después de una revisión de 475 artículos, se incluyeron ocho artículos, y al ser evaluados fueron clasificados cinco artículos 2+ y tres 2-, con nivel de reco-mendación D. Conclusión. La dermatoglifía es una herramienta útil como medio de detección de la DM. Sin embargo, es necesario realizar estudios de cohortes para demostrarlo en di-ferentes poblaciones, como la colombiana. En ese sentido, se encuentra que el 70% de los artículos revisados demuestran que la predicción de hallazgo de DM es efectiva. Sin embargo, el 30% de las investigaciones dentro de esta revisión no consideran que sea una herramienta lo suficientemente óptima para descubrir la patología en la población.

Introduction. Diabetes mellitus (DM) is one of the most common chronic diseases, be-ing one of the main causes of mortality in the world population. Dermatoglyphics is used as an instrument for the discovery of certain biological aspects in different populations.Objective. To recognize, by doing a systematic review, the relevance of dermato-glyphics as a means of finding diabetes mellitus. Methodology. Review of scientific literature in databases such as Sciencedirect, PubMed, Scopus, and VHL, in which information was extracted after running the search equation with MESH terms. After that, they were revised to include those articles related to DM and dermatoglyphics. For the entire process, the PRISMA methodology was followed, evaluating the articles with the Cochrane bias scale and the level of evidence and recommendation with the SIGN scale. Results. After a review of 475 articles, eight articles were included, and when evalu-ated, five articles were classified as 2+ and three as 2-, with a level D recommendation. Conclusion. Dermatoglyphics is a useful tool as a means of detecting DM. However, it is necessary to carry out cohort studies to demonstrate this in different populations, such as the Colombian population. 70% of the reviewed articles show that the prediction of DM finding is effective. Nevertheless, 30% of the investigations within this review do not consider it to be a sufficiently optimal tool to discover the pathology in the population

Revisión sistemática entre dermatoglifia dactilar y fuerza en el deporte a nivel mundial / Systematic review between fingerprint dermatoglyphics and strength in sport worldwide

RESUMEN La Dermatoglifia ha sido utilizada como herramienta para identificar la relación de esta con las capacidades físicas dentro de diferentes tipos de disciplinas deportivas. El presente documento tuvo como objetivo, identificar los hallazgos de investigaciones a nivel mundial, mostrando los resultados existentes entre los dermatoglifos y la capacidad de la fuerza en el rendimiento deportivo. Método: la búsqueda incluye publicaciones en revistas indexadas en los idiomas inglés, portugués y español. Se utilizaron las siguientes bases de datos: Scopus, Scielo, Redalyc, Pubmed, Sportdiscus, Science Direct y Biblioteca Regional de Salud, para la búsqueda de información se definieron varias palabras clave. Se realizó la búsqueda y luego la revisión, donde se identificaron 56 artículos, de los cuales seis cumplieron con los criterios de inclusión. Resultados y conclusiones: se evidenció que la mayor parte de investigaciones son casos y controles, algunos con altos niveles de sesgo por eso su clasificación fue de 2+ y 3 (Escala SIGN). Los resultados en esta revisión sustentan la relación entre la predominancia del patrón de Presilla y el desarrollo de la fuerza sin discriminar tipo de deporte, género y edad de los practicantes, país de procedencia, composición corporal o características genéticas.

ABSTRACT Dermatoglyphics have been used as a tool to identify its relationship with physical capacities within different types of sports disciplines. The present document aimed to identify research findings worldwide, showing the existing results between dermatoglyphics and the force capacity in sports performance. Method: The search includes publications in indexed journals in the English, Portuguese and Spanish languages. The following databases were used: Scopus, Scielo, Redalyc, Pubmed, Sportdiscus, Science Direct and Regional Health Library, for the information search several key words were defined. The search and then the review were carried out, where 56 articles were identified, of which 6 met the inclusion criteria. Results and conclusions: It was evidenced that most of the investigations are cases and controls, some with high levels of bias, which is why their classification was 2+ and 3 (SIGN Scale). The results in this review support the relationship between the predominance of the Clip pattern and the development of strength without discriminating type of sport, gender and age of the practitioners, country of origin, body composition or genetic characteristics.

Dermatoglifia y fuerza muscular en deportistas de baloncesto universitario / Dermatoglyphics and muscle strength in college basketball players / Dermatoglifia e força muscular em atletas de basquete universitári

RESUMEN El baloncesto es un deporte que requiere capacidades físicas para su desenvolvimiento en cualquier nivel de competencia; la fuerza es uno de los parámetros a evaluar que más exactitud precisa y que puede ayudar a llevar al deportista a su máximo potencial, por esto el objetivo del estudio fue determinar la relación entre las variables dermatoglifia y fuerza muscular en las posiciones de juego del baloncesto universitario, teniendo en cuenta el perfil antropométrico, en jugadores (mujeres y hombres) entre los 17 y 23 años. La muestra fue con 15 atletas de la selección de baloncesto, donde se evaluaron variables dermatoglificas (metodología propuesta por Cummins & Midlo, 1942), medidas antropométricas (la báscula InBody 770 y tallímetro SECA), posición de juego de cada individuo y test de fuerza muscular (T-force, modelo TF-100). Se encontró que la variable de dermatoglifia que más correlación (alta y moderada) tuvo con la prueba de fuerza muscular fueron los Arcos y dentro de este se encontraban los Postes, quienes en esta posición de juego mostraron mayor relación (r= 0,525 p= 0,045). Se demostró que, puede encontrar un lazo entre dos variables como dermatoglifia y fuerza muscular, sin embargo, es importante contar con una muestra más amplia y discriminarla por género, para así tener mayor exactitud.

ABSTRACT Basketball is a sport that requires physical abilities for its development at any level of competition; strength is an evaluated parameter that is more accurate than others and that can help to take the athlete to their maximum potential. For this reason, the objective of this study is to determine the relationship between the dermatoglyphics and muscle strength variables in university basketball playing positions, taking into account the anthropometric profile, in players (women and men) between 17 and 23 years old. The sample consisted of 15 athletes from the basketball team, where dermatoglyphic variables (methodology proposed by Cummins & Midlo, 1942), anthropometric measurements (the InBody 770 scale and SECA height rod), playing position of each individual, and muscle strength test (T-force, model TF-100) were evaluated. The dermatoglyphics variable that had the most correlation (high and moderate) with the muscle strength test were the arches, and within these, were the posts, who, in this playing position, showed the greatest relationship (r = 0.525 p = 0.045). It was shown that you can find a link between two variables such as dermatoglyphics and muscle strength, however, it is important to have a larger sample and discriminate it by gender, in order to have a higher accuracy.

SUMÁRIO O basquete é um esporte que requer habilidades físicas para seu desenvolvimento em qualquer nível de competição; a força é um dos parâmetros a serem avaliados mais precisos e que podem ajudar a levar o atleta ao seu potencial máximo; por esse motivo, o do estudo foi determinar a relação entre as variáveis dermatoglíficas e a força muscular nas posições de jogo de basquete de universidade, considerando o perfil antropométrico, em jogadores (mulheres e homens) entre 17 e 23 anos de idade. A amostra foi composta por 15 atletas do time de basquete, onde variáveis dermatoglíficas (metodologia proposta por Cummins & Midlo, 1942), medidas antropométricas (escala InBody 770 e estadiômetro SECA), posição de jogo de cada indivíduo e teste de força muscular (força T, modelo TF-100). Para análise estatística, foi realizado no software SPSS versão 22, com tendência central (média e desvio padrão). Verificou-se que a variável dermatoglyphic que teve a maior correlação (alta e moderada) com o teste de força muscular foram os Arcos e dentro deste foram os posts, que nesta posição de jogo apresentaram a maior relação (r = 0,525 p = 0,045). Foi demonstrado que, se é possível encontrar um vínculo entre duas variáveis, como dermatoglifos e força muscular, é importante ter uma amostra maior e discriminá-la por sexo, a fim de obter maior precisão.

Huellas dactilares: origen, usos y desafíos que genera la incapacidad para su registro / Fingerprints: origin, uses and challenges in the face of its verification failure

Considerando que las huellas dactilares son impresiones de las crestas epidérmicas de los dedos con un patrón único, irrepetible y permanente, estas son la base del método biométrico más empleado en la actualidad. Entre sus diversos usos destaca la identificación para múltiples actividades como acceder al trabajo o a teléfonos celulares, la operación de cuentas bancarias, las investigaciones criminales, etcétera. La ausencia o deterioro de las crestas epidérmicas, denominada adermatoglifia, impide la identificación por biometría dactilar. La adermatoglifia se origina por múltiples causas, incluyendo las enfermedades dermatológicas, lesiones traumáticas de los dedos, denervación, envejecimiento, quimioterapia, entre otras. Abordamos brevemente el origen, usos y sistemas para el registro de las huellas dactilares. El objetivo principal es enfatizar la existencia de personas con incapacidad para registrar sus huellas, una condición relevante por el riesgo potencial de discriminación, especialmente cuando el registro de las huellas es obligatorio.

Considering that fingerprints are impressions of the epidermal ridges of the fingers with a unique, unrepeatable, and permanent pattern, they are the basis of the biometric identification method most used today. Among its various uses stand out identification for multiple activities such as authentication to access work and cell phones, operation of bank accounts, criminal investigations, etc. The absence or deterioration of the epidermal ridges, called adermatoglyphia, prevents identification by finger biometrics. Adermatoglyphia originates from multiple causes, including several skin diseases, traumatic injuries of the fingers, denervation, aging, chemotherapy, among others. The origin, uses, and systems for fingerprints verification are briefly addressed here. The main objective is to emphasize the existence of people with fingerprint verification failure, a relevant condition due to the potential risk of discrimination, especially when fingerprint verification is mandatory.

Fenotipos clínicos en el síndrome de apnea obstructiva del sueño / Clinical phenotypes in obstructive sleep apnea

El síndrome de apnea e hipopnea obstructiva del sueño se caracteriza por episodios repetitivos de obstrucción de vía aérea superior y es reconocida cada vez más, como un trastorno heterogéneo y complejo, proponiéndose múltiples fenotipos en base a su mecanismo patogénico, alteraciones polisomnográficas y la presentación clínica. El fenotipo clínico se enfoca en identificar características de un paciente basándose en signos, síntomas, antropometría, comorbilidades, medidas fisiológicas, anatómicas o respuesta al tratamiento. Al ser una enfermedad sub diagnosticada, de alta prevalencia y que produce elevada morbi-mortalidad, se debe estar atento a la pesquisa precoz y en las poblaciones de riesgo. Su diagnóstico se basa en el índice de apnea-hipopnea (IAH) y se requiere un IAH •5 eventos/hora para confirmar el diagnóstico. Sin embargo, cada vez hay más evidencia que el IAH por sí solo es insuficiente para comprender la presentación clínica, respuesta al tratamiento, calidad de vida y mortalidad de los pacientes con apnea del sueño. El fenotipo clínico puede servir de este modo, para entender mejor las diferentes formas de presentación teniendo como finalidad la medicina personalizada con el objetivo de favorecer la conducta terapéutica individualizada. El objetivo de esta revisión es abordar los fenotipos clínicos y proponer una huella digital en los pacientes con apnea del sueño

Obstructive sleep apnea and hypopnea syndrome is characterized by repetitive episodes of upper airway obstruction and is increasingly recognized as a heterogeneous and complex disorder, proposing multiple phenotypes based on its pathogenic mechanism, polysomnographic alterations, and clinical presentation. The clinical phenotype focuses on identifying a patient's characteristics based on signs, symptoms, anthropometry, comorbidities, physiological, anatomical measures or response to treatment. As it is an underdiagnosed disease of high prevalence associated to high morbidity and mortality, we must be alert to early screening and risk populations. Diagnosis is based on the apnea-hypopnea index (AHI) AHI •5 events/hour is required to confirm it, however, there is increasing evidence that AHI alone is insufficient to understand the clinical presentation, the response to treatment, the quality of life and the mortality of patients with sleep apnea. In this way, the clinical phenotype can serve to better understand the different forms of presentation and looks for a personalized medicine that favors an individualized therapeutic behavior. The aim of this review is to address clinical phenotypes and propose a fingerprint in patients with sleep apnea

Precisión de los sistemas de impresión digital intraoral en odontología restauradora: Una revisión de la literatura / Accuracy of Intraoral Digital Impression Systems in Restorative Dentistry: A Review of the Literature

Abstract: La impresión intraoral permite al odontólogo obtener directamente los datos de las piezas dentales que se requiera rehabilitar, otorgándole mayor precisión y eliminando así de la fase clínica la toma de impresión y la fabricación del modelo, aspectos sensibles a errores. El objetivo de la presente revisión es identificar el sistema de impresión digital intraoral más preciso y además identificar los factores que afectan a la precisión de esta en odontología restauradora. Mediante una revisión bibliográfica con búsqueda en las bases de datos de PubMed y Embase se obtuvieron 153 artículos, luego de la evaluación cualitativa se incluyeron en la revisión 14 que cumplieron con los criterios de inclusión y exclusión. Se determinó que la experiencia del dentista, la convergencia en la preparación dental y la terminación cervical son determinantes al momento de la toma de impresión digital, sin embargo, el uso o no de polvo no es relevante. El sistema de impresión digital Lava C.O.S., iTero y True definition son los más precisos dependiendo siempre del tipo de rehabilitación a realizar.

Abstract: Digital impresión allows the dentist to directly obtain the data of the dental pieces that neet to be rehabilitated, giving it greater precisión and thus eliminating the impression and manufacturing of the dental model, error-sensitive aspects of the clinical phase. The aim of this review is to identify the most accurate intraoral digital impression system and identifiy the factors that affect the accuracy in the restorative dentistry. Through a bibliographic review with search in PubMed and Embase databases, 153 articles were obtained, after qualitative evaluation they were included in the revisión 14 that met the inclusion and exclusion criteria. It was determined that the experience of the dentist, the convergence in the dental preparation and the cervical termination are decisive at the accuracy of the digital impression, however, the use or not of dust is not relevant. The Lava C.O.S., iTero and True definition are the most accurate always depending on the type of rehabilitation to be performed.

Analysis of implementation outcomes of quality improvement initiatives in Haiti: the fingerprint initiative / Análisis de los resultados de la puesta en práctica de iniciativas para la mejora de la calidad en Haití: la iniciativa de la huella dactilar / Análise dos resultados da implantação de iniciativas para melhoria da qualidade no Haiti: iniciativa de leitura da impressão digital

ABSTRACT Objective. To assess the process and outcomes of the implementation of an electronic fingerprint initiative as part of quality improvement in three health facilities in the Northern Department of Haiti, in terms of its acceptability, adoption, feasibility, fidelity, and sustainability. In Haiti, poor attendance of the healthcare workforce is a nationwide problem, closely related to the quality of care. Three health institutions have tried to implement an electronic fingerprint system to monitor and improve attendance. Methods. An exploratory and qualitative descriptive study of the implementation outcomes of the fingerprint initiative. It was based on semi-structured interviews and one group discussion using purposeful sampling techniques to recruit participants, and an open coding system and deductive approach to analyze the data using ATLAS.ti 8. Results. The fingerprint initiative was successfully implemented in a non-governmental organization supported health facility but, despite some planning, it was never implemented in the public health facilities. The acceptability of the implementation was high in the not-for-profit organization and low in the public settings, mostly in relation to the presence of champions and the leadership at each health facility. Conclusions. We recommend more involvement of the leadership of health facilities in the different phases of the implementation process in order to guarantee acceptability, adoption, fidelity and sustainabiliy. More research is needed to articulate this technology-driven initiative in the Haitian health system.

RESUMEN Objetivo. Evaluar el proceso y los resultados de la puesta en práctica de una iniciativa de digitalización de huellas dactilares como parte de la mejora de la calidad en tres establecimientos de salud del departamento Norte de Haití, en cuanto a su aceptabilidad, adopción, viabilidad, fidelidad y sostenibilidad. En Haití, el absentismo de los trabajadores de atención de salud es un problema nacional, estrechamente relacionado con la calidad de la atención. Tres instituciones de salud han tratado de poner en práctica un sistema de huellas dactilares digitalizadas para monitorear y mejorar la asistencia. Métodos. Se ha llevado a cabo un estudio descriptivo cualitativo y exploratorio de los resultados de la puesta en práctica de la iniciativa de la huella dactilar. Este estudio empleó entrevistas semiestructuradas y una discusión de grupo mediante técnicas de muestreo con fines específicos para reclutar a los participantes, y un sistema de codificación abierta y enfoque deductivo para analizar los datos con ATLAS.ti 8. Resultados. La iniciativa de la huella dactilar se llevó a cabo satisfactoriamente en un establecimiento de salud no gubernamental; sin embargo, a pesar de cierta planificación, no llegó a ponerse en práctica en establecimientos públicos de salud. La aceptabilidad de la implementación fue alta en las organizaciones sin fines de lucro y baja en los entornos públicos, principalmente en lo que respecta a la presencia de líderes y dirigentes en cada establecimiento de salud. Conclusiones. Recomendamos una mayor participación de la gerencia de los establecimientos de salud en las diferentes fases del proceso de ejecución para garantizar aceptabilidad, adopción, fidelidad y sostenibilidad. Se necesita investigación adicional para integrar esta iniciativa impulsada por la tecnología en el sistema de salud haitiano.

RESUMO Objetivo. Avaliar o processo e os resultados da implantação de uma iniciativa de controle de ponto eletrônico por biometria para melhoria da qualidade em três serviços de saúde no Departamento Norte do Haiti quanto à aceitabilidade, adoção, viabilidade, fidelidade e sustentabilidade. A baixa assiduidade no trabalho do pessoal da saúde é um problema em todo o país e está estreitamente relacionada à qualidade da atenção. Foi feita uma tentativa de implantar um sistema de ponto eletrônico por biometria em três instituições de saúde, para monitorar e aumentar a assiduidade no trabalho. Métodos. Estudo exploratório, descritivo e qualitativo dos resultados da implantação da iniciativa de ponto eletrônico por biometria. Os dados foram coletados em entrevistas semiestruturadas e em um grupo de discussão usando técnica de amostragem intencional para recrutar os participantes. A análise de dados foi realizada por codificação aberta e enfoque dedutivo com o uso do software ATLAS.ti 8. Resultados. A iniciativa de ponto eletrônico por biometria foi implantada com êxito em um serviço de saúde apoiado por uma organização não governamental. Porém, apesar do planejamento, ela nunca foi implantada nos serviços da rede pública. A aceitabilidade foi muito boa na entidade sem fins lucrativos, mas foi baixa na rede pública, sobretudo em relação à presença de apoiadores e dirigentes no local. Conclusões. Recomenda-se maior envolvimento dos dirigentes dos serviços de saúde nas diferentes fases do processo de implantação para garantir a aceitabilidade, adoção, fidelidade e sustentabilidade da iniciativa. Mais pesquisas são necessárias para estruturar esta iniciativa com uso de tecnologia no sistema de saúde do Haiti.

Molecular Techniques to Study Microbial Wastewater Communities

Abstract wastewater treatment (WT) is of major importance on modern cities, removing wastewater pollutants resultant from anthropogenic activities. The unique abilities of microbes to degrade organic matter, remove nutrients and transform toxic compounds into harmless products make them essential players in waste treatment. The microbial diversity determines the metabolic pathways that may occur in WT and quality of treated wastewater. Therefore, understanding WT microbial community structure, distribution, and metabolic functioning is essential for development and optimization of efficient microbial engineering systems. Since cultivation methods can only detect a small fraction of the microbial diversity, the use of culture-independent molecular methods has circumvented this issue, allowing unprecedented access to genes and genomes used for microbial composition and function evaluation. Traditional approaches like RAPD, DGGE, ARDRA, RISA, SSCP, T-RFLP, and FISH and modern approaches like microarray, qPCR, and metagenomics are essential techniques for identifying and depicting the total microbial community structure and their interaction with environmental and biotic factors. Thus, this review describes traditional and state of the art molecular techniques which provide insights into phylogenetic and functional activities of microbial assemblages in a WT system.

Influencia del IMC en la huella plantar de árbitros masculinos de fútbol / Influence of BMI on the Footprint of Male Soccer Referees

RESUMEN Introducción: Los árbitros desempeñan un rol fundamental y determinante dentro del sistema de juego competitivo del fútbol. Identificar la relación entre las modificaciones de la composición antropométrica con relación al estado nutricional podría mejorar la comprensión del rendimiento de los árbitros. Objetivo: Determinar la influencia del índice de masa corporal en la huella plantar de los árbitros de fútbol. Métodos: Estudio exploratorio-correlacional con análisis cuantitativo. La muestra estuvo conformada por 28 árbitros masculinos con una edad de 22,43 ± 3,30 años. Se recolectó información sobre talla y peso, con lo que se determinó el índice de masa corporal (IMC); además, se recolectó información para la huella plantar a partir de los indicadores de: ancho del antepié (X), ancho del mediopié (Y), anchura complementaria (AY), ancho del retropié (AT), índice de huella (% X) y longitud de pie (LP) en ambos pies. El análisis del coeficiente correlacional fue efectuado en PSPP (p-valor de 0,05). Resultados: El promedio del IMC de los participantes fue normal y la clasificación del tipo de pie fue Normal/cavo para ambos; por otra parte, el IMC tiene una correlación significativa con X (r = 0,50; p = 0,01) y AT (r = 0,46; p = 0,01) del pie izquierdo, en cambio el IMC y X obtuvo una relación muy significativa (r = 0,59; p = 0), y evidenció una relación significativa (r = 0,39; p = 0,04) al igual que AT (r = 0,40; p = 0,04). Conclusiones: Se considera que el IMC afecta la huella plantar de los árbitros de fútbol)AU)

ABSTRACT Introduction: Referees play a fundamental and determining role within the soccer competitive game system. Identifying the relationship between changes in anthropometric composition in relation to nutritional status could improve the understanding of referees' performance. Objective: To determine the influence of the body mass index (BMI) on the footprint of soccer referees. Methods: An exploratory-correlational study with quantitative analysis was carried out in 28 male referees aging 22.43 ± 3.30 years who made up the sample. Information on height and weight was collected, to determine their body mass index (BMI). In addition, information was collected for the plantar footprint from the indicators of forefoot width (X), midfoot width (Y), complementary width (AY), hindfoot width (AT), footprint index (% X) and foot length (LP) on both feet. The correlation coefficient analysis was carried out in PSPP (p-value of 0.05). Results: The average BMI of the participants in this study was normal and the classification of the type of foot was normal / cavus for both. On the other hand, the BMI has significant correlation with X (r = 0.50; p = 0.01) and AT (r = 0.46; p = 0.01) of the left foot, while the BMI and X obtained a very significant relationship (r = 0.59; p = 0), and was significantly related (r = 0.39; p = 0.04) as well as AT (r = 0.40; p = 0, 04). Conclusions: BMI is considered to affect the footprint of soccer referees(AU)

Relação entre baropodometria, podoscopia e plantigrafia na avaliação da impressão plantar / Relationship between baropodometry, podoscopy and plantigraphy in the evaluation of plantar printing

Objetivo ­ Analisar a relação entre baropodometria, podoscopia e plantigrafia na avaliação da impressão plantar. Métodos ­ Foram analisados 26 indivíduos voluntários com idade entre 20 e 25 anos, de ambos os sexos, sem restrição quanto à raça, que não referiram dor aguda ou crônica, que não foram submetidos a qualquer procedimento cirúrgico em membros inferiores e que não apresentassem disfunções neurológicas e vestibulares. Os indivíduos foram submetidos aos exames de baropodometria, podoscopia e plantigrafia no mesmo dia, recebendo as mesmas orientações em todas as medições, sendo realizadas três coletas em cada equipamento. Na análise da impressão plantar foi utilizado o Índice de Chippaux-Smirak (CSI), que classifica o arco longitudinal medial de acordo com cinco categorias: pé com arco elevado, pé com arco morfologicamente normal, pé intermediário, pé com arco reduzido, pé plano. Resultados ­ Foram utilizadas duas análises estatísticas: o Índice de Kappa e o Teste de ANOVA. A análise do arco plantar feita pela plantigrafia encontrou uma média de 0,346 classificando os pés como intermediários. No podoscópio a média foi de 0,237 e na baropodometria de 0,141, ambos classificando os pés como morfologicamente normais. Verifica-se que não houve concordância quanto à classificação do arco nos três equipamentos simultaneamente (p=0,372), além de existir uma grande variação das médias amostrais (p<0,001). Conclusão ­ Não houve uma relação direta entre baropodometria, podoscopia e plantigrafia na avaliação da impressão plantar

Objective ­ To analyze the relationship between baropodometry, podoscopy and plantigraphy in the evaluation of the footprint. Methods ­ 26 voluntary individuals aged between 20 and 25 years old, of both sexes, without ethinia restriction, did not report acute or chronic pain, did not undergo any surgical procedure on the lower limbs and did not present any dysfunction, were analyzed neurological and vestibular. The individuals were submitted to baropodometry, podoscopy and plantigraphy exams on the same day, receiving the same guidelines in all measurements, with three collections being performed on each equipment. In the analysis of the footprint, the Chippaux-Smirak Index (CSI) was used, which classifies the medial longitudinal arch according to five categories: foot with elevated arch, foot with morphologically normal arch, intermediate foot, foot with reduced arch, flat foot. Results ­ Two statistical analyzes were used: the Kappa Index and the ANOVA Test. The analysis of the plantar arch made by plantigraphy found an average of 0.346 classifying the feet as intermediate. In the podoscope the average was 0.237 and in baropodometry 0.141, both classifying the feet as morphologically normal. It appears that there was no agreement regarding the classification of the arc in the three devices simultaneously (p=0.372), in addition to a large variation in the sample means (p<0.001). Conclusion ­ There was no direct relationship between baropodometry, podoscopy and plantigraphy in the evaluation of the footprint.

Prediction of Drug–Drug Interactions by Using Profile Fingerprint Vectors and Protein Similarities / 대한의료정보학회지

Dermatoglyphic traits of brazilian golfers / Traços dermatoglíficos dos golfistas brasileiros

ABSTRACT Played all over the world, golf has gained popularity, for it is a sport that depends on individual abilities. For this reason the search for tools that aim to seek and guide its respective talented players has become very important. Therefore, this study had the objective of comparing the distribution of the dermatoglyphic indicators of high performance golfers and of a group control of non-athletes. The sample was composed of 46 individuals with paired age and gender, divided into two groups: the Group Golf (GG), composed of 23 golfers, and the Group Control (GC), composed of 23 individuals control randomly selected. The golfers, part of the Project Golf Brazil of the Brazilian Golf Confederation, were between 11 and 21 years old. The results demonstrated that the number of lines in the pattern was of six possible variables of fingerprint (MESQL1, MESQL2, MESQL4, MESQL5, SQTLE, SQTL) is significantly higher in the golfers (GG) when compared to the group control (GC). When observed the qualitative variables, i. e., the pattern type, significant diferences where observed between the groups, since the golfers (GG) presented more Radial Loops (RL) in MDT5 when compared to the group control (GC). The results found in this study demonstrated that the dermatoglyphic profile of high performance golfers differ from the non-athlete population.

RESUMO Jogado em todo o mundo, o golfe está ganhando popularidade, sendo um esporte que depende das habilidades individuais, tornando-se importante a busca por ferramentas que visem buscar e orientar seus respectivos talentos. O presente estudo teve por objetivo comparar a distribuição dos indicadores dermatoglíficos de golfistas de alto rendimento e de um grupo controle de não atletas. A amostra foi composta por 46 indivíduos com idade e sexo pareados, divididos em dois grupos: o Grupo Golf (GG), composto por 23 golfistas e o Grupo Controle (GC), composto por 23 indivíduos controle aleatoriamente selecionados. Os golfistas, parte do Projeto Golf Brasil da Confederação Brasileira de Golfe, tinham idade entre 11 e 21 anos. Os resultados demonstram que o número de linhas no padrão de seis possíveis variáveis de impressão digital (MESQL1, MESQL2, MESQL4, MESQL5, SQTLE, SQTL) é maior nos golfistas (GG) quando comparado ao grupo controle (GC). Quando observadas as variáveis qualitativas, ou seja, o tipo de figura, observaram-se diferenças significativas entre os grupos, visto que os Golfistas (GG) apresentaram maior quantidade de Presilha Radial (LR) no MDT5 quando comparados ao grupo controle (GC). Os resultados encontrados neste estudo demonstraram que o perfil dermatoglífico de golfistas de alto rendimento difere da população não atleta.

LGR5 and Downstream Intracellular Signaling Proteins Play Critical Roles in the Cell Proliferation of Neuroblastoma, Meningioma and Pituitary Adenoma

Leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5) has been reported to play critical roles in the proliferation of various cancer cells. However, the roles of LGR5 in brain tumors and the specific intracellular signaling proteins directly associated with it remain unknown. Expression of LGR5 was first measured in normal brain tissue, meningioma, and pituitary adenoma of humans. To identify the downstream signaling pathways of LGR5, siRNA-mediated knockdown of LGR5 was performed in SH-SY5Y neuroblastoma cells followed by proteomics analysis with 2-dimensional polyacrylamide gel electrophoresis (2D-PAGE). In addition, the expression of LGR5-associated proteins was evaluated in LGR5-inhibited neuroblastoma cells and in human normal brain, meningioma, and pituitary adenoma tissue. Proteomics analysis showed 12 protein spots were significantly different in expression level (more than two-fold change) and subsequently identified by peptide mass fingerprinting. A protein association network was constructed from the 12 identified proteins altered by LGR5 knockdown. Direct and indirect interactions were identified among the 12 proteins. HSP 90-beta was one of the proteins whose expression was altered by LGR5 knockdown. Likewise, we observed decreased expression of proteins in the hnRNP subfamily following LGR5 knockdown. In addition, we have for the first time identified significantly higher hnRNP family expression in meningioma and pituitary adenoma compared to normal brain tissue. Taken together, LGR5 and its downstream signaling play critical roles in neuroblastoma and brain tumors such as meningioma and pituitary adenoma.

Diagnosis and Management of Hip Dislocation in Patients with Kabuki Syndrome

BACKGROUND: Kabuki syndrome is a rare genetic disorder characterized by distinct dysmorphic facial features, growth deficiency, intellectual disabilities, unusual dermatoglyphic patterns, and skeletal abnormalities. The incidence of hip dislocation in Kabuki syndrome ranges from 18% to 62%. We reviewed the outcomes of management of hip dislocations in patients with Kabuki syndrome with special attention to the diagnostic processes for hip dislocation and Kabuki syndrome. METHODS: Among 30 patients with mutation-confirmed Kabuki syndrome, we selected six patients who had hip dislocations and reviewed their medical records and plain radiographs. The modes of presentation and diagnostic processes for both hip dislocations and Kabuki syndrome were investigated. The management and treatment outcomes of hip dislocations in patients with Kabuki syndrome were evaluated. RESULTS: The average age of patients at the time of diagnosis of hip dislocation was 7.7 months (range, 1 week to 22 months). None of the patients were diagnosed as having Kabuki syndrome at that time. Two patients were treated with a Pavlik harness; one, with closed reduction; two, with open reduction and later pelvic and/or femoral osteotomies; and one, with open reduction combined with pelvic osteotomy. The patients were followed up for 5.8 years on average (range, 2.0 to 10.5 years). The radiologic outcome was graded as Severin IA or IB for three patients who were older than 6 years at the latest follow-up (mean age, 9.9 years; range, 7.8 to 12.4 years). In the remaining three patients younger than 6 years (mean age, 3.8 years; range, 2.7 to 5.3 years), the lateral center edge angle was more than 15°. The clinical diagnosis of Kabuki syndrome was made during follow-up after hip dislocation treatment and confirmed by mutational analysis at a mean age of 4.7 years. The mean interval between the diagnosis of hip dislocation and Kabuki syndrome was 4.0 years. CONCLUSIONS: The management of hip dislocation by conservative or surgical method showed successful results. Awareness of Kabuki syndrome could lead to an early diagnosis of this rare disease in patients with hip dislocation and allow for early detection of other underlying conditions and multidisciplinary management.

Distinct Urinary Metabolic Profile in Rheumatoid Arthritis Patients: A Possible Link between Diet and Arthritis Phenotype

OBJECTIVE: We undertook this study to investigate the discriminant metabolites in urine from patients with established rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and from healthy individuals. METHODS: Urine samples were collected from 148 RA patients, 41 SLE patients and 104 healthy participants. The urinary metabolomic profiles were assessed using 1H nuclear magnetic resonance spectroscopy. The relationships between discriminant metabolites and clinical variables were assessed. Collagen-induced arthritis was induced in mice to determine if a choline-rich diet reduces arthritis progression. RESULTS: The urinary metabolic fingerprint of patients with established RA differs from that of healthy controls and SLE patients. Markers of altered gut microbiota (trimethylamine-N-oxide, TMAO), and oxidative stress (dimethylamine) were upregulated in patients with RA. In contrast, markers of mitochondrial dysfunction (citrate and succinate) and metabolic waste products (p-cresol sulfate, p-CS) were downregulated in patients with RA. TMAO and dimethylamine were negatively associated with serum inflammatory markers in RA patients. In particular, patients with lower p-CS levels exhibited a more rapid radiographic progression over two years than did those with higher p-CS levels. The in vivo functional study demonstrated that mice fed with 1% choline, a source of TMAO experienced a less severe form of collagen-induced arthritis than did those fed a control diet. CONCLUSION: Patients with RA showed a distinct urinary metabolomics pattern. Urinary metabolites can reflect a pattern indicative of inflammation and accelerated radiographic progression of RA. A choline-rich diet reduces experimentally-induced arthritis. This finding suggests that the interaction between diet and the intestinal microbiota contributes to the RA phenotype.